# OnCo record paper-sartore-bianchi-heracles-trastuzumab-lapatinib-lancet-oncol-2016 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
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<https://onco.cc/key-papers/paper-sartore-bianchi-heracles-trastuzumab-lapatinib-lancet-oncol-2016/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-sartore-bianchi-heracles-trastuzumab-lapatinib-lancet-oncol-2016" ;
  schema:name "Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES)"@en ;
  schema:description "A trial designed from mouse avatars: screening 914 patients found 48 with HER2-amplified bowel cancer, and blocking HER2 two ways shrank tumours in 30 percent of the 27 who were treated."@en ;
  schema:url <https://onco.cc/key-papers/paper-sartore-bianchi-heracles-trastuzumab-lapatinib-lancet-oncol-2016/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/S1470-2045(16)00150-9>, <https://pubmed.ncbi.nlm.nih.gov/27108243/> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1016/S1470-2045(16)00150-9> ;
  schema:datePublished "2016"^^xsd:gYear ;
  schema:author "Sartore-Bianchi A, Trusolino L, Martino C, et al." ;
  onco:related <https://onco.cc/key-papers/paper-tcga-colon-rectal-molecular-characterization-nature-2012/>, <https://onco.cc/key-papers/paper-strickler-mountaineer-tucatinib-trastuzumab-lancet-oncol-2023/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/her2-amplified-colorectal/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/her2/>, <https://onco.cc/targets/kras/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/lapatinib/> ;
  onco:people <https://onco.cc/people/salvatore-siena/>, <https://onco.cc/people/alberto-bardelli/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-rare-cancers/>, <https://onco.cc/bottlenecks/b-trial-enrolment/>, <https://onco.cc/bottlenecks/b-preclinical-models/> ;
  onco:journals <https://onco.cc/journals/lancet-oncology/> .