# OnCo record paper-scher-affirm-enzalutamide-nejm-2012 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-scher-affirm-enzalutamide-nejm-2012/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-scher-affirm-enzalutamide-nejm-2012" ;
  schema:name "AFFIRM: increased survival with enzalutamide in prostate cancer after chemotherapy"@en ;
  schema:alternateName "AFFIRM"@en, "Scher 2012 enzalutamide"@en, "MDV3100 AFFIRM"@en ;
  schema:description "Enzalutamide, an oral tablet that blocks the androgen receptor at several points at once, added nearly five months to median survival in men whose cancer had already been through chemotherapy. More than half had their PSA halve, against two percent on placebo."@en ;
  schema:url <https://onco.cc/key-papers/paper-scher-affirm-enzalutamide-nejm-2012/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/nejmoa1207506>, <https://pubmed.ncbi.nlm.nih.gov/22894553/>, <https://clinicaltrials.gov/study/NCT00974311> ;
  onco:tag "prostate-evidence" ;
  schema:sameAs <https://doi.org/10.1056/nejmoa1207506> ;
  schema:datePublished "2012"^^xsd:gYear ;
  schema:author "Scher HI, Fizazi K, Saad F, et al." ;
  onco:related <https://onco.cc/key-papers/paper-beer-prevail-enzalutamide-nejm-2014/>, <https://onco.cc/key-papers/paper-chen-androgen-receptor-overexpression-antiandrogen-resistance-nat-med-2004/>, <https://onco.cc/key-papers/paper-cou-aa-301-abiraterone-de-bono-nejm-2011/>, <https://onco.cc/roadmaps/prostate-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:sections <https://onco.cc/fronts/hormonal/>, <https://onco.cc/fronts/targeted-therapy/> ;
  onco:targets <https://onco.cc/targets/androgen-receptor/> ;
  onco:drugs <https://onco.cc/drugs/enzalutamide/> ;
  onco:companies <https://onco.cc/companies/astellas/>, <https://onco.cc/companies/pfizer/> ;
  onco:terms <https://onco.cc/terms/castration-resistance/>, <https://onco.cc/terms/psa/>, <https://onco.cc/terms/quality-of-life/>, <https://onco.cc/terms/radiographic-progression-free-survival/> ;
  onco:people <https://onco.cc/people/howard-scher/>, <https://onco.cc/people/karim-fizazi/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:journals <https://onco.cc/journals/nejm/> .
