# OnCo record paper-seshagiri-rspo-fusions-colon-nature-2012 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-seshagiri-rspo-fusions-colon-nature-2012/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-seshagiri-rspo-fusions-colon-nature-2012" ;
  schema:name "Recurrent R-spondin fusions in colon cancer"@en ;
  schema:description "Sequencing the DNA and the RNA of more than 70 colon tumours turned up a new way of switching on the growth signal that drives the disease: two genes fused so that an amplifier of the WNT pathway is overproduced, in tumours whose usual brake gene is intact."@en ;
  schema:url <https://onco.cc/key-papers/paper-seshagiri-rspo-fusions-colon-nature-2012/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature11282>, <https://pubmed.ncbi.nlm.nih.gov/22895193/>, <https://www.cbioportal.org/study/summary?id=coadread_genentech> ;
  schema:sameAs <https://doi.org/10.1038/nature11282> ;
  schema:datePublished "2012"^^xsd:gYear ;
  schema:author "Seshagiri S, Stawiski EW, Durinck S, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/rna-seq/> ;
  onco:targets <https://onco.cc/targets/rspo3/>, <https://onco.cc/targets/rspo2/>, <https://onco.cc/targets/tcf7l2/>, <https://onco.cc/targets/apc/>, <https://onco.cc/targets/atm/> ;
  onco:pathways <https://onco.cc/pathways/wnt/>, <https://onco.cc/pathways/rtk-activation/> ;
  onco:terms <https://onco.cc/terms/gene-fusion/> ;
  onco:journals <https://onco.cc/journals/nature/> .