# OnCo record paper-shaw-alk-l1198f-resensitisation-nejm-2016 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-shaw-alk-l1198f-resensitisation-nejm-2016/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-shaw-alk-l1198f-resensitisation-nejm-2016" ;
  schema:name "Resensitization to crizotinib by the lorlatinib ALK resistance mutation L1198F"@en ;
  schema:description "A patient's cancer became resistant to one drug, then to a second, then to a third, and the mutation that defeated the third drug made the first one work again. She was rechallenged with it and recovered."@en ;
  schema:url <https://onco.cc/key-papers/paper-shaw-alk-l1198f-resensitisation-nejm-2016/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1508887>, <https://pubmed.ncbi.nlm.nih.gov/26698910/> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa1508887> ;
  schema:datePublished "2016"^^xsd:gYear ;
  schema:author "Shaw AT, Friboulet L, Leshchiner I, et al." ;
  onco:related <https://onco.cc/biomarkers/alk-fusion/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/alk/> ;
  onco:drugs <https://onco.cc/drugs/crizotinib/>, <https://onco.cc/drugs/lorlatinib/> ;
  onco:institutions <https://onco.cc/institutions/mgh/> ;
  onco:pathways <https://onco.cc/pathways/resistance-routes-map/>, <https://onco.cc/pathways/rtk-activation/>, <https://onco.cc/pathways/clonal-evolution/> ;
  onco:terms <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/cross-resistance/> ;
  onco:people <https://onco.cc/people/alice-shaw/> ;
  onco:journals <https://onco.cc/journals/nejm/> .