# OnCo record paper-shaw-alk-resistance-mutations-lorlatinib-jco-2019 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-shaw-alk-resistance-mutations-lorlatinib-jco-2019/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-shaw-alk-resistance-mutations-lorlatinib-jco-2019" ;
  schema:name "ALK resistance mutations and efficacy of lorlatinib in advanced anaplastic lymphoma kinase-positive non-small-cell lung cancer"@en ;
  schema:description "In patients whose cancer had already outgrown a second ALK drug, the third-generation drug worked in seven out of ten of those whose tumour carried a resistance mutation and in fewer than three out of ten of those whose tumour did not."@en ;
  schema:url <https://onco.cc/key-papers/paper-shaw-alk-resistance-mutations-lorlatinib-jco-2019/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.18.02236>, <https://pubmed.ncbi.nlm.nih.gov/30892989/> ;
  schema:sameAs <https://doi.org/10.1200/JCO.18.02236> ;
  schema:datePublished "2019"^^xsd:gYear ;
  schema:author "Shaw AT, Solomon BJ, Besse B, et al." ;
  onco:related <https://onco.cc/biomarkers/alk-fusion/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/alk/>, <https://onco.cc/targets/ros1/> ;
  onco:drugs <https://onco.cc/drugs/lorlatinib/>, <https://onco.cc/drugs/crizotinib/>, <https://onco.cc/drugs/guardant360-cdx/> ;
  onco:institutions <https://onco.cc/institutions/mgh/> ;
  onco:pathways <https://onco.cc/pathways/resistance-routes-map/>, <https://onco.cc/pathways/rtk-activation/> ;
  onco:terms <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/ctdna/> ;
  onco:people <https://onco.cc/people/alice-shaw/> ;
  onco:journals <https://onco.cc/journals/jco/> .
