# OnCo record paper-shaw-crown-lorlatinib-crizotinib-nejm-2020 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-shaw-crown-lorlatinib-crizotinib-nejm-2020/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-shaw-crown-lorlatinib-crizotinib-nejm-2020" ;
  schema:name "First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer"@en ;
  schema:description "CROWN's third-generation ALK drug kept 78 percent of patients free of progression at a year against 39 percent on crizotinib, and controlled disease inside the brain far better."@en ;
  schema:url <https://onco.cc/key-papers/paper-shaw-crown-lorlatinib-crizotinib-nejm-2020/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2027187>, <https://pubmed.ncbi.nlm.nih.gov/33207094/>, <https://clinicaltrials.gov/study/NCT03052608> ;
  onco:tag "lung-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2027187> ;
  schema:datePublished "2020"^^xsd:gYear ;
  schema:author "Shaw AT, Bauer TM, de Marinis F, et al." ;
  onco:related <https://onco.cc/key-papers/paper-peters-alex-alectinib-crizotinib-nejm-2017/>, <https://onco.cc/key-papers/paper-kwak-crizotinib-alk-nsclc-nejm-2010/>, <https://onco.cc/ideas/idea-bio2-brain-met-prevention-trials/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/alk-positive-nsclc/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/alk/>, <https://onco.cc/targets/ros1/> ;
  onco:drugs <https://onco.cc/drugs/lorlatinib/>, <https://onco.cc/drugs/crizotinib/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:terms <https://onco.cc/terms/brain-metastases/>, <https://onco.cc/terms/resistance/> ;
  onco:trials <https://onco.cc/trials/crown/> ;
  onco:people <https://onco.cc/people/alice-shaw/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-brain-delivery/>, <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:journals <https://onco.cc/journals/nejm/> .