# OnCo record paper-shine-ibrutinib-bendamustine-rituximab-mantle-cell-nejm-2022 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-shine-ibrutinib-bendamustine-rituximab-mantle-cell-nejm-2022/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-shine-ibrutinib-bendamustine-rituximab-mantle-cell-nejm-2022" ;
  schema:name "Ibrutinib plus bendamustine and rituximab in untreated mantle-cell lymphoma"@en ;
  schema:alternateName "SHINE"@en, "Wang 2022"@en ;
  schema:description "Adding a targeted tablet to first-line chemotherapy gave older people with mantle cell lymphoma about two and a half more years before relapse, without helping them live longer."@en ;
  schema:url <https://onco.cc/key-papers/paper-shine-ibrutinib-bendamustine-rituximab-mantle-cell-nejm-2022/> ;
  schema:dateModified "2026-10-01"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2201817>, <https://pubmed.ncbi.nlm.nih.gov/35657079/>, <https://europepmc.org/article/MED/35657079> ;
  onco:tag "lymphoma-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2201817> ;
  schema:datePublished "2022"^^xsd:gYear ;
  schema:author "Wang ML, Jurczak W, Jerkeman M, et al." ;
  onco:related <https://onco.cc/roadmaps/lymphoma-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/mantle-cell-lymphoma/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/>, <https://onco.cc/fronts/chemotherapy/> ;
  onco:targets <https://onco.cc/targets/btk/>, <https://onco.cc/targets/cd20/>, <https://onco.cc/targets/ccnd1/> ;
  onco:drugs <https://onco.cc/drugs/ibrutinib/>, <https://onco.cc/drugs/bendamustine/>, <https://onco.cc/drugs/rituximab/> ;
  onco:companies <https://onco.cc/companies/johnson-johnson/> ;
  onco:pathways <https://onco.cc/pathways/bcr-signalling/> ;
  onco:terms <https://onco.cc/terms/maintenance-therapy/> ;
  onco:trials <https://onco.cc/trials/shine/>, <https://onco.cc/trials/enrich/>, <https://onco.cc/trials/nct02972840/> ;
  onco:people <https://onco.cc/people/michael-wang/>, <https://onco.cc/people/martin-dreyling/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-aging-comorbidity/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:journals <https://onco.cc/journals/nejm/> .