# OnCo record paper-shiva-off-label-targeted-therapy-lancet-oncol-2015 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-shiva-off-label-targeted-therapy-lancet-oncol-2015/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-shiva-off-label-targeted-therapy-lancet-oncol-2015" ;
  schema:name "SHIVA: molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer"@en ;
  schema:description "The one randomised test of giving people a targeted drug matched to their tumour's mutation but outside its licence found they did no better than with their doctor's choice of treatment."@en ;
  schema:url <https://onco.cc/key-papers/paper-shiva-off-label-targeted-therapy-lancet-oncol-2015/> ;
  schema:dateModified "2026-10-20"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/S1470-2045(15)00188-6>, <https://pubmed.ncbi.nlm.nih.gov/26342236/>, <https://clinicaltrials.gov/study/NCT01771458> ;
  onco:tag "precision", "failure" ;
  schema:sameAs <https://doi.org/10.1016/S1470-2045(15)00188-6> ;
  schema:datePublished "2015"^^xsd:gYear ;
  schema:author "Le Tourneau C, Delord JP, Gonçalves A, et al." ;
  onco:sections <https://onco.cc/fronts/diagnostics/> ;
  onco:technologies <https://onco.cc/technologies/cgp/> ;
  onco:people <https://onco.cc/people/christophe-le-tourneau/> ;
  onco:journals <https://onco.cc/journals/lancet-oncology/> .