# OnCo record paper-siena-destiny-crc01-trastuzumab-deruxtecan-lancet-oncol-2021 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-siena-destiny-crc01-trastuzumab-deruxtecan-lancet-oncol-2021/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-siena-destiny-crc01-trastuzumab-deruxtecan-lancet-oncol-2021" ;
  schema:name "Trastuzumab deruxtecan (DS-8201) in patients with HER2-expressing metastatic colorectal cancer (DESTINY-CRC01)"@en ;
  schema:description "An antibody carrying a chemotherapy payload shrank 45 percent of HER2-positive bowel cancers that had already failed two or more treatments, including tumours that had progressed on other HER2 drugs."@en ;
  schema:url <https://onco.cc/key-papers/paper-siena-destiny-crc01-trastuzumab-deruxtecan-lancet-oncol-2021/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/S1470-2045(21)00086-3>, <https://pubmed.ncbi.nlm.nih.gov/33961795/> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1016/S1470-2045(21)00086-3> ;
  schema:datePublished "2021"^^xsd:gYear ;
  schema:author "Siena S, Di Bartolomeo M, Raghav K, et al." ;
  onco:related <https://onco.cc/key-papers/paper-strickler-mountaineer-tucatinib-trastuzumab-lancet-oncol-2023/>, <https://onco.cc/key-papers/paper-sartore-bianchi-heracles-trastuzumab-lapatinib-lancet-oncol-2016/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/her2-amplified-colorectal/> ;
  onco:sections <https://onco.cc/fronts/adcs/>, <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:companies <https://onco.cc/companies/daiichi-sankyo/> ;
  onco:trials <https://onco.cc/trials/destiny-crc02/> ;
  onco:people <https://onco.cc/people/salvatore-siena/>, <https://onco.cc/people/yoshino-takayuki/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-rare-cancers/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:journals <https://onco.cc/journals/lancet-oncology/> .