# OnCo record paper-skoulidis-kras-co-mutation-subsets-cancer-discov-2015 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-skoulidis-kras-co-mutation-subsets-cancer-discov-2015/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-skoulidis-kras-co-mutation-subsets-cancer-discov-2015" ;
  schema:name "Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities"@en ;
  schema:description "Lung cancers driven by a mutated KRAS gene behave so differently from one another that they are better thought of as three diseases, and which of the three a patient has depends on the second gene that is broken."@en ;
  schema:url <https://onco.cc/key-papers/paper-skoulidis-kras-co-mutation-subsets-cancer-discov-2015/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/2159-8290.CD-14-1236>, <https://pubmed.ncbi.nlm.nih.gov/26069186/> ;
  schema:sameAs <https://doi.org/10.1158/2159-8290.CD-14-1236> ;
  schema:datePublished "2015"^^xsd:gYear ;
  schema:author "Skoulidis F, Byers LA, Diao L, et al." ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/rna-seq/>, <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/stk11/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/cdkn2a/>, <https://onco.cc/targets/nkx2-1/>, <https://onco.cc/targets/keap1/>, <https://onco.cc/targets/pdl1/> ;
  onco:institutions <https://onco.cc/institutions/md-anderson/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/t-cell-exhaustion/>, <https://onco.cc/pathways/keap1-nrf2/>, <https://onco.cc/pathways/pi3k-akt-mtor/> ;
  onco:terms <https://onco.cc/terms/kras-mutation-subtypes/>, <https://onco.cc/terms/stk11-keap1/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:people <https://onco.cc/people/ferdinandos-skoulidis/> ;
  onco:journals <https://onco.cc/journals/cancer-discovery/> .