# OnCo record paper-soda-eml4-alk-fusion-nature-2007 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-soda-eml4-alk-fusion-nature-2007/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-soda-eml4-alk-fusion-nature-2007" ;
  schema:name "Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer"@en ;
  schema:description "A small inversion on chromosome 2 fuses two genes and makes a kinase that drives lung cancer. Soda and Mano found it in 5 of 75 tumours, and a drug for it was approved four years later."@en ;
  schema:url <https://onco.cc/key-papers/paper-soda-eml4-alk-fusion-nature-2007/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature05945>, <https://pubmed.ncbi.nlm.nih.gov/17625570/>, <https://doi.org/10.1038/nature05945> ;
  onco:tag "lung-evidence" ;
  schema:sameAs <https://doi.org/10.1038/nature05945> ;
  schema:datePublished "2007"^^xsd:gYear ;
  schema:author "Soda M, Choi YL, Enomoto M, et al." ;
  onco:related <https://onco.cc/key-papers/paper-kwak-crizotinib-alk-nsclc-nejm-2010/>, <https://onco.cc/key-papers/paper-alk-nsclc-n-engl-j-med-2013/>, <https://onco.cc/roadmaps/targeted-therapy-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/alk-positive-nsclc/>, <https://onco.cc/cancers/lung-adenocarcinoma/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/>, <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/terms/fish/>, <https://onco.cc/terms/ihc/>, <https://onco.cc/terms/ngs/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/alk/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/crizotinib/> ;
  onco:pathways <https://onco.cc/pathways/rtk-activation/>, <https://onco.cc/pathways/nsclc-signalling/> ;
  onco:terms <https://onco.cc/terms/driver-mutation/>, <https://onco.cc/terms/oncogene-addiction/>, <https://onco.cc/terms/gene-fusion/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-translational-valley/>, <https://onco.cc/bottlenecks/b-generic-repurposing/> ;
  onco:journals <https://onco.cc/journals/nature/> .