# OnCo record paper-spearhead-1-lancet-2024 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-spearhead-1-lancet-2024/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-spearhead-1-lancet-2024" ;
  schema:name "SPEARHEAD-1: afamitresgene autoleucel, the first engineered T-cell receptor therapy approved for a solid tumour, in synovial sarcoma"@en ;
  schema:description "T cells taken from patients and engineered to recognise the MAGE-A4 protein shrank tumours in about four in ten patients with advanced synovial sarcoma, leading to the first approval of a TCR T-cell therapy for any solid cancer."@en ;
  schema:url <https://onco.cc/key-papers/paper-spearhead-1-lancet-2024/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://pubmed.ncbi.nlm.nih.gov/?term=SPEARHEAD-1+afamitresgene+autoleucel+synovial+sarcoma+Lancet>, <https://clinicaltrials.gov/study/NCT04044768>, <https://pubmed.ncbi.nlm.nih.gov/?term=SPEARHEAD-1%20afamitresgene%20autoleucel%20synovial%20sarcoma%20D'Angelo%20Lancet%202024> ;
  schema:sameAs <https://doi.org/10.1016/S0140-6736(24)00319-2> ;
  schema:datePublished "2024"^^xsd:gYear ;
  schema:author "D'Angelo SP, Araujo DM, Abdul Razak AR, et al." ;
  onco:related <https://onco.cc/key-papers/paper-c-144-01-lifileucel-melanoma-jco-2021/> ;
  onco:cancers <https://onco.cc/cancers/sarcoma/> ;
  onco:technologies <https://onco.cc/technologies/tcr-t/> ;
  onco:targets <https://onco.cc/targets/mage-a4/> ;
  onco:drugs <https://onco.cc/drugs/afamitresgene-autoleucel/>, <https://onco.cc/drugs/letetresgene-autoleucel/> ;
  onco:companies <https://onco.cc/companies/adaptimmune/> ;
  onco:terms <https://onco.cc/terms/orr/>, <https://onco.cc/terms/crs/>, <https://onco.cc/terms/accelerated-approval/> ;
  onco:people <https://onco.cc/people/jean-yves-blay/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-rare-cancers/>, <https://onco.cc/bottlenecks/b-manufacturing-cell-therapy/>, <https://onco.cc/bottlenecks/b-trial-diversity/> ;
  onco:journals <https://onco.cc/journals/lancet/> .