# OnCo record paper-tauriello-tgfbeta-immune-evasion-colorectal-nature-2018 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-tauriello-tgfbeta-immune-evasion-colorectal-nature-2018/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-tauriello-tgfbeta-immune-evasion-colorectal-nature-2018" ;
  schema:name "TGF-beta drives immune evasion in genetically reconstituted colon cancer metastasis"@en ;
  schema:description "Mice given all four of the main bowel cancer mutations grew tumours that spread and, like most human bowel cancers, ignored immunotherapy. Blocking TGF-beta let the immune system in, stopped the spread, and made the tumours answer checkpoint drugs."@en ;
  schema:url <https://onco.cc/key-papers/paper-tauriello-tgfbeta-immune-evasion-colorectal-nature-2018/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature25492>, <https://pubmed.ncbi.nlm.nih.gov/29443964/> ;
  schema:sameAs <https://doi.org/10.1038/nature25492> ;
  schema:datePublished "2018"^^xsd:gYear ;
  schema:author "Tauriello DVF, Palomo-Ponce S, Stork D, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:targets <https://onco.cc/targets/tgfb1/>, <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/apc/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/smad4/> ;
  onco:pathways <https://onco.cc/pathways/tgf-beta/>, <https://onco.cc/pathways/immune-desert-exclusion/>, <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/metastatic-cascade/> ;
  onco:terms <https://onco.cc/terms/cold-vs-hot/>, <https://onco.cc/terms/immune-exclusion/>, <https://onco.cc/terms/mss-pmmr/> ;
  onco:journals <https://onco.cc/journals/nature/> .