# OnCo record paper-tcga-colon-rectal-molecular-characterization-nature-2012 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-tcga-colon-rectal-molecular-characterization-nature-2012/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-tcga-colon-rectal-molecular-characterization-nature-2012" ;
  schema:name "Comprehensive molecular characterization of human colon and rectal cancer"@en ;
  schema:description "The Cancer Genome Atlas read 276 bowel cancers end to end and found that colon and rectal tumours are genetically the same disease, that one in six is hypermutated, and that a few carry a HER2 amplification that a drug could hit."@en ;
  schema:url <https://onco.cc/key-papers/paper-tcga-colon-rectal-molecular-characterization-nature-2012/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature11252>, <https://pubmed.ncbi.nlm.nih.gov/22810696/>, <https://europepmc.org/article/MED/22810696> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1038/nature11252> ;
  schema:datePublished "2012"^^xsd:gYear ;
  schema:author "Cancer Genome Atlas Network." ;
  onco:related <https://onco.cc/key-papers/paper-cms-guinney-nat-med-2015/>, <https://onco.cc/key-papers/paper-vogelstein-genetic-alterations-colorectal-tumor-development-nejm-1988/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/colon-cancer/>, <https://onco.cc/cancers/rectal-cancer/>, <https://onco.cc/cancers/msi-high-colorectal/>, <https://onco.cc/cancers/her2-amplified-colorectal/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/terms/ngs/> ;
  onco:targets <https://onco.cc/targets/apc/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/smad4/>, <https://onco.cc/targets/her2/>, <https://onco.cc/pathways/myc/> ;
  onco:pathways <https://onco.cc/pathways/wnt/>, <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/targets/mmr/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tumor-heterogeneity/> ;
  onco:journals <https://onco.cc/journals/nature/> .