# OnCo record paper-tcga-lung-squamous-nature-2012 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-tcga-lung-squamous-nature-2012/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-tcga-lung-squamous-nature-2012" ;
  schema:name "Comprehensive genomic characterization of squamous cell lung cancers"@en ;
  schema:description "The first complete genomic reading of 178 squamous lung cancers found a chaotic genome with almost universal loss of the p53 gene, and identified a possible drug target in most tumours in a cancer that until then had none."@en ;
  schema:url <https://onco.cc/key-papers/paper-tcga-lung-squamous-nature-2012/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature11404>, <https://pubmed.ncbi.nlm.nih.gov/22960745/>, <https://www.cbioportal.org/study/summary?id=lusc_tcga_pub> ;
  schema:sameAs <https://doi.org/10.1038/nature11404> ;
  schema:datePublished "2012"^^xsd:gYear ;
  schema:author "Cancer Genome Atlas Research Network." ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/rna-seq/>, <https://onco.cc/technologies/methylation-profiling/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/cdkn2a/>, <https://onco.cc/targets/rb1/>, <https://onco.cc/targets/nfe2l2/>, <https://onco.cc/targets/keap1/>, <https://onco.cc/targets/cul3/>, <https://onco.cc/targets/pik3ca/>, <https://onco.cc/targets/pten/>, <https://onco.cc/targets/sox2/>, <https://onco.cc/targets/tp63/>, <https://onco.cc/targets/fgfr1/>, <https://onco.cc/targets/hla-a/>, <https://onco.cc/targets/notch1/> ;
  onco:institutions <https://onco.cc/institutions/broad-institute/> ;
  onco:pathways <https://onco.cc/pathways/nsclc-signalling/>, <https://onco.cc/pathways/keap1-nrf2/>, <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/antigen-presentation-immunoediting/> ;
  onco:terms <https://onco.cc/terms/gene-amplification/>, <https://onco.cc/terms/copy-number-variation-term/>, <https://onco.cc/terms/driver-mutation/> ;
  onco:journals <https://onco.cc/journals/nature/> .