# OnCo record paper-teply-restore-bipolar-androgen-therapy-lancet-oncol-2018 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-teply-restore-bipolar-androgen-therapy-lancet-oncol-2018/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-teply-restore-bipolar-androgen-therapy-lancet-oncol-2018" ;
  schema:name "RESTORE: bipolar androgen therapy after progression on enzalutamide in metastatic castration-resistant prostate cancer"@en ;
  schema:alternateName "RESTORE"@en, "Teply 2018 bipolar androgen therapy"@en, "BAT after enzalutamide"@en ;
  schema:description "Prostate cancer adapts to having almost no testosterone. This trial did the opposite of what the textbook says and gave men large doses of testosterone. Three in ten responded, and more than half responded again to the hormone-blocking drug that had stopped working."@en ;
  schema:url <https://onco.cc/key-papers/paper-teply-restore-bipolar-androgen-therapy-lancet-oncol-2018/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/s1470-2045(17)30906-3>, <https://pubmed.ncbi.nlm.nih.gov/29248236/>, <https://clinicaltrials.gov/study/NCT02090114> ;
  onco:tag "prostate-evidence" ;
  schema:sameAs <https://doi.org/10.1016/s1470-2045(17)30906-3> ;
  schema:datePublished "2018"^^xsd:gYear ;
  schema:author "Teply BA, Wang H, Luber B, et al." ;
  onco:related <https://onco.cc/key-papers/paper-denmeade-transformer-bipolar-androgen-therapy-jco-2021/>, <https://onco.cc/key-papers/paper-chen-androgen-receptor-overexpression-antiandrogen-resistance-nat-med-2004/>, <https://onco.cc/ideas/idea-bio1-alternating-schedules/>, <https://onco.cc/roadmaps/prostate-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:sections <https://onco.cc/fronts/hormonal/> ;
  onco:targets <https://onco.cc/targets/androgen-receptor/> ;
  onco:drugs <https://onco.cc/drugs/enzalutamide/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:terms <https://onco.cc/terms/castration-resistance/>, <https://onco.cc/terms/psa/>, <https://onco.cc/terms/bipolar-androgen-therapy/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-generic-repurposing/>, <https://onco.cc/bottlenecks/b-combination-space/> ;
  onco:journals <https://onco.cc/journals/lancet-oncology/> .