# OnCo record paper-tie-dynamic-ctdna-guided-adjuvant-stage-ii-colon-nejm-2022 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-tie-dynamic-ctdna-guided-adjuvant-stage-ii-colon-nejm-2022/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-tie-dynamic-ctdna-guided-adjuvant-stage-ii-colon-nejm-2022" ;
  schema:name "Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer (DYNAMIC)"@en ;
  schema:description "The first randomised trial to let a blood test decide who gets chemotherapy. It halved chemotherapy use in stage II colon cancer with no loss of recurrence-free survival."@en ;
  schema:url <https://onco.cc/key-papers/paper-tie-dynamic-ctdna-guided-adjuvant-stage-ii-colon-nejm-2022/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2200075>, <https://pubmed.ncbi.nlm.nih.gov/35657320/>, <https://europepmc.org/article/MED/35657320> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2200075> ;
  schema:datePublished "2022"^^xsd:gYear ;
  schema:author "Tie J, Cohen JD, Lahouel K, et al." ;
  onco:related <https://onco.cc/ideas/idea-ctdna-guided-adjuvant-crc/>, <https://onco.cc/key-papers/paper-tie-ctdna-minimal-residual-disease-stage-ii-colon-sci-transl-med-2016/>, <https://onco.cc/key-papers/paper-kotani-galaxy-molecular-residual-disease-nat-med-2023/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/colon-cancer/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/>, <https://onco.cc/fronts/chemotherapy/> ;
  onco:technologies <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/drugs/signatera/> ;
  onco:institutions <https://onco.cc/institutions/wehi/>, <https://onco.cc/institutions/peter-mac/> ;
  onco:terms <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/mrd/>, <https://onco.cc/terms/neoadjuvant-adjuvant/> ;
  onco:trials <https://onco.cc/trials/dynamic/> ;
  onco:people <https://onco.cc/people/jeanne-tie/>, <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/kenneth-kinzler/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dormancy-mrd/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:journals <https://onco.cc/journals/nejm/> .