# OnCo record paper-tomlins-tmprss2-ets-fusion-science-2005 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
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<https://onco.cc/key-papers/paper-tomlins-tmprss2-ets-fusion-science-2005/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-tomlins-tmprss2-ets-fusion-science-2005" ;
  schema:name "Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer"@en ;
  schema:alternateName "Tomlins 2005"@en, "TMPRSS2-ERG fusion"@en, "TMPRSS2-ETV1"@en ;
  schema:description "Gene fusions were thought to be a feature of leukaemias, not common solid cancers. This study found one in prostate cancer that joins a switch controlled by testosterone to a growth gene, and found it in most of the tumours it looked at."@en ;
  schema:url <https://onco.cc/key-papers/paper-tomlins-tmprss2-ets-fusion-science-2005/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.1117679>, <https://pubmed.ncbi.nlm.nih.gov/16254181/> ;
  onco:tag "prostate-evidence" ;
  schema:sameAs <https://doi.org/10.1126/science.1117679> ;
  schema:datePublished "2005"^^xsd:gYear ;
  schema:author "Tomlins SA, Rhodes DR, Perner S, et al." ;
  onco:related <https://onco.cc/key-papers/paper-taylor-integrative-genomic-profiling-cancer-cell-2010/>, <https://onco.cc/key-papers/paper-tcga-molecular-taxonomy-primary-prostate-cell-2015/>, <https://onco.cc/roadmaps/prostate-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-high-risk/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/>, <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/technologies/cytogenetics-fish/>, <https://onco.cc/technologies/rna-seq/> ;
  onco:targets <https://onco.cc/targets/erg/>, <https://onco.cc/targets/tmprss2/>, <https://onco.cc/targets/androgen-receptor/>, <https://onco.cc/targets/etv1/> ;
  onco:institutions <https://onco.cc/institutions/michigan-rogel/> ;
  onco:pathways <https://onco.cc/pathways/prostate-cancer-signalling/>, <https://onco.cc/pathways/ar-signaling/>, <https://onco.cc/pathways/transcription-addiction/> ;
  onco:terms <https://onco.cc/terms/ngs/>, <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/fish/>, <https://onco.cc/terms/driver-mutation/> ;
  onco:people <https://onco.cc/people/arul-chinnaiyan/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-biomarker-validation/> ;
  onco:journals <https://onco.cc/journals/science/> .