# OnCo record paper-tropion-breast01-jco-2024 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-tropion-breast01-jco-2024/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-tropion-breast01-jco-2024" ;
  schema:name "TROPION-Breast01: datopotamab deruxtecan versus chemotherapy in pretreated hormone-receptor-positive breast cancer, and why a PFS win did not translate to survival"@en ;
  schema:description "The TROP2-directed antibody-drug conjugate Dato-DXd delayed progression by about two months compared with chemotherapy, but patients did not live longer, which stalled its approval in breast cancer."@en ;
  schema:url <https://onco.cc/key-papers/paper-tropion-breast01-jco-2024/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://pubmed.ncbi.nlm.nih.gov/?term=TROPION-Breast01+datopotamab+deruxtecan+Bardia>, <https://clinicaltrials.gov/study/NCT05104866> ;
  schema:sameAs <https://doi.org/10.1200/JCO.24.00920> ;
  schema:datePublished "2024"^^xsd:gYear ;
  schema:author "Bardia A, Jhaveri K, Im SA, et al." ;
  onco:related <https://onco.cc/ideas/idea-trop2-pet-selection/>, <https://onco.cc/ideas/idea-payload-switching/> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/trop2/> ;
  onco:drugs <https://onco.cc/drugs/datopotamab-deruxtecan/> ;
  onco:companies <https://onco.cc/companies/daiichi-sankyo/>, <https://onco.cc/companies/astrazeneca/> ;
  onco:terms <https://onco.cc/terms/pfs/>, <https://onco.cc/terms/os/>, <https://onco.cc/terms/adc-sequencing/>, <https://onco.cc/terms/ihc/> ;
  onco:trials <https://onco.cc/trials/tropion-breast01/>, <https://onco.cc/trials/tropion-breast02/> ;
  onco:people <https://onco.cc/people/im-seock-ah/>, <https://onco.cc/people/xu-binghe/>, <https://onco.cc/people/barrios-carlos/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-negative-results/> ;
  onco:journals <https://onco.cc/journals/jco/> .