# OnCo record paper-tropion-breast02-ann-oncol-2026 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-tropion-breast02-ann-oncol-2026/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-tropion-breast02-ann-oncol-2026" ;
  schema:name "Datopotamab deruxtecan in patients with untreated, advanced triple-negative breast cancer (TROPION-Breast02): a randomised, open-label, international, phase III trial"@en ;
  schema:description "The trial of 644 women with newly metastatic triple-negative breast cancer who could not have immunotherapy, in which the antibody-drug conjugate datopotamab deruxtecan held the cancer still for 10.8 months against 5.6 with chemotherapy and lengthened life from 18.7 to 23.7 months."@en ;
  schema:url <https://onco.cc/key-papers/paper-tropion-breast02-ann-oncol-2026/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.annonc.2026.03.008>, <https://pubmed.ncbi.nlm.nih.gov/41937088/>, <https://clinicaltrials.gov/study/NCT05374512> ;
  onco:tag "tnbc-evidence" ;
  schema:sameAs <https://doi.org/10.1016/j.annonc.2026.03.008> ;
  schema:datePublished "2026"^^xsd:gYear ;
  schema:author "Dent R, Shao Z, Schmid P, et al." ;
  onco:related <https://onco.cc/roadmaps/trop2-adc-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/tnbc/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/trop2/> ;
  onco:drugs <https://onco.cc/drugs/datopotamab-deruxtecan/> ;
  onco:companies <https://onco.cc/companies/astrazeneca/>, <https://onco.cc/companies/daiichi-sankyo/> ;
  onco:terms <https://onco.cc/terms/pfs/>, <https://onco.cc/terms/os/>, <https://onco.cc/terms/adc-sequencing/> ;
  onco:trials <https://onco.cc/trials/tropion-breast02/>, <https://onco.cc/trials/tropion-breast05/>, <https://onco.cc/trials/ascent-03/> ;
  onco:people <https://onco.cc/people/rebecca-dent/>, <https://onco.cc/people/peter-schmid/>, <https://onco.cc/people/javier-cortes/> ;
  onco:journals <https://onco.cc/journals/annals-of-oncology/> .