# OnCo record paper-tukachinsky-ctdna-3334-advanced-prostate-ccr-2021 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-tukachinsky-ctdna-3334-advanced-prostate-ccr-2021/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-tukachinsky-ctdna-3334-advanced-prostate-ccr-2021" ;
  schema:name "Genomic analysis of circulating tumour DNA in 3,334 patients with advanced prostate cancer identifies targetable BRCA alterations and AR resistance mechanisms"@en ;
  schema:description "The largest blood-based study in advanced prostate cancer found detectable tumour DNA in nineteen men out of twenty, agreed with tissue on BRCA faults nine times out of ten, and found resistance changes tissue had missed."@en ;
  schema:url <https://onco.cc/key-papers/paper-tukachinsky-ctdna-3334-advanced-prostate-ccr-2021/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/1078-0432.CCR-20-4805>, <https://pubmed.ncbi.nlm.nih.gov/33558422/> ;
  schema:sameAs <https://doi.org/10.1158/1078-0432.CCR-20-4805> ;
  schema:datePublished "2021"^^xsd:gYear ;
  schema:author "Tukachinsky H, Madison RW, Chung JH, et al." ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/brca/>, <https://onco.cc/targets/androgen-receptor/>, <https://onco.cc/targets/atm/>, <https://onco.cc/targets/chek2/> ;
  onco:pathways <https://onco.cc/pathways/homologous-recombination-repair/>, <https://onco.cc/pathways/ar-signaling/>, <https://onco.cc/pathways/clonal-haematopoiesis/>, <https://onco.cc/pathways/resistance-routes-map/> ;
  onco:terms <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/cfdna/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/terms/germline-vs-somatic/>, <https://onco.cc/terms/gbrca-mutation/> ;
  onco:journals <https://onco.cc/journals/clinical-cancer-research/> .