# OnCo record paper-tumeh-pd1-adaptive-immune-resistance-nature-2014 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-tumeh-pd1-adaptive-immune-resistance-nature-2014/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-tumeh-pd1-adaptive-immune-resistance-nature-2014" ;
  schema:name "Tumeh 2014: PD-1 blockade works by releasing T cells already present at the tumour edge"@en ;
  schema:description "Melanomas that responded to pembrolizumab already contained killer T cells pressed up against tumour cells expressing PD-L1, showing that the drug works by releasing an immune attack that is already there rather than creating a new one."@en ;
  schema:url <https://onco.cc/key-papers/paper-tumeh-pd1-adaptive-immune-resistance-nature-2014/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature13954> ;
  schema:sameAs <https://doi.org/10.1038/nature13954> ;
  schema:datePublished "2014"^^xsd:gYear ;
  schema:author "Tumeh PC, Harview CL, Yearley JH, et al." ;
  onco:related <https://onco.cc/key-papers/paper-rizvi-mutational-landscape-pd1-science-2015/> ;
  onco:cancers <https://onco.cc/cancers/melanoma/> ;
  onco:targets <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/pdl1/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/> ;
  onco:institutions <https://onco.cc/institutions/ucla-jonsson/> ;
  onco:terms <https://onco.cc/terms/tils/>, <https://onco.cc/terms/immune-checkpoint/> ;
  onco:people <https://onco.cc/people/antoni-ribas/> .