# OnCo record paper-van-cutsem-crystal-cetuximab-folfiri-nejm-2009 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-van-cutsem-crystal-cetuximab-folfiri-nejm-2009/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-van-cutsem-crystal-cetuximab-folfiri-nejm-2009" ;
  schema:name "Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer (CRYSTAL)"@en ;
  schema:description "The trial that added an EGFR antibody to first-line chemotherapy and, in the same paper, showed the benefit belongs only to patients whose KRAS gene is normal. It is the first negative predictive biomarker in bowel cancer."@en ;
  schema:url <https://onco.cc/key-papers/paper-van-cutsem-crystal-cetuximab-folfiri-nejm-2009/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa0805019>, <https://pubmed.ncbi.nlm.nih.gov/19339720/> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa0805019> ;
  schema:datePublished "2009"^^xsd:gYear ;
  schema:author "Van Cutsem E, Köhne CH, Hitre E, et al." ;
  onco:related <https://onco.cc/key-papers/paper-kras-colorectal-j-clin-oncol-2011/>, <https://onco.cc/key-papers/paper-kras-colorectal-j-clin-oncol-2008/>, <https://onco.cc/key-papers/paper-douillard-prime-panitumumab-ras-nejm-2013/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/kras/> ;
  onco:drugs <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/folfiri/>, <https://onco.cc/drugs/irinotecan/>, <https://onco.cc/drugs/fluorouracil/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/sidedness/> ;
  onco:trials <https://onco.cc/trials/crystal-fire3/> ;
  onco:people <https://onco.cc/people/eric-van-cutsem/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/> ;
  onco:journals <https://onco.cc/journals/nejm/> .