# OnCo record paper-vogelstein-cancer-genome-landscapes-science-2013 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-vogelstein-cancer-genome-landscapes-science-2013/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-vogelstein-cancer-genome-landscapes-science-2013" ;
  schema:name "Cancer genome landscapes: about 140 driver genes, and each tumour needs only a handful"@en ;
  schema:description "Synthesising the first generation of cancer genome sequencing, Vogelstein and colleagues concluded that about 140 genes can drive cancer when mutated, that a typical solid tumour has 2 to 8 driver mutations among tens of passengers, and that all drivers act through a dozen signalling pathways."@en ;
  schema:url <https://onco.cc/key-papers/paper-vogelstein-cancer-genome-landscapes-science-2013/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.1235122> ;
  schema:sameAs <https://doi.org/10.1126/science.1235122> ;
  schema:datePublished "2013"^^xsd:gYear ;
  schema:author "Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW" ;
  onco:related <https://onco.cc/key-papers/paper-tcga-pancancer-atlas-cell-2018/>, <https://onco.cc/key-papers/paper-detect-a-science-2020/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/>, <https://onco.cc/fronts/diagnostics/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/pik3ca/>, <https://onco.cc/targets/braf/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:terms <https://onco.cc/terms/oncogene-addiction/>, <https://onco.cc/terms/tmb/>, <https://onco.cc/terms/mutational-signature/> ;
  onco:people <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/kenneth-kinzler/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-tumor-heterogeneity/>, <https://onco.cc/bottlenecks/b-early-detection/> ;
  onco:journals <https://onco.cc/journals/science/> .
