# OnCo record paper-vogelstein-genetic-alterations-colorectal-development-nejm-1988 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-vogelstein-genetic-alterations-colorectal-development-nejm-1988/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-vogelstein-genetic-alterations-colorectal-development-nejm-1988" ;
  schema:name "Genetic alterations during colorectal-tumor development"@en ;
  schema:description "By counting four genetic changes in 172 bowel growths at every stage from small polyp to cancer, this study showed that the changes pile up in step with the disease, and gave cancer research its first map of how one cancer forms."@en ;
  schema:url <https://onco.cc/key-papers/paper-vogelstein-genetic-alterations-colorectal-development-nejm-1988/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJM198809013190901>, <https://pubmed.ncbi.nlm.nih.gov/2841597/> ;
  schema:sameAs <https://doi.org/10.1056/NEJM198809013190901> ;
  schema:datePublished "1988"^^xsd:gYear ;
  schema:author "Vogelstein B, Fearon ER, Hamilton SR, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/apc/>, <https://onco.cc/targets/smad4/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:pathways <https://onco.cc/pathways/colorectal-cancer-signalling/>, <https://onco.cc/pathways/chromosomal-instability/> ;
  onco:terms <https://onco.cc/terms/driver-mutation/> ;
  onco:people <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/eric-fearon/> ;
  onco:journals <https://onco.cc/journals/nejm/> .