# OnCo record paper-vogelstein-genetic-alterations-colorectal-tumor-development-nejm-1988 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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a schema:ScholarlyArticle ;
onco:kind "paper" ;
schema:identifier "paper-vogelstein-genetic-alterations-colorectal-tumor-development-nejm-1988" ;
schema:name "Genetic alterations during colorectal-tumor development"@en ;
schema:description "The 1988 study of 172 bowel tumours that showed cancer is not one mutation but a sequence of them, accumulating as a polyp grows into a cancer. It is the origin of the idea that cancer develops step by step."@en ;
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schema:dateModified "2026-09-24"^^xsd:date ;
schema:citation , , ;
onco:tag "colorectal-evidence" ;
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schema:datePublished "1988"^^xsd:gYear ;
schema:author "Vogelstein B, Fearon ER, Hamilton SR, et al." ;
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onco:cancers , ;
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onco:technologies ;
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