# OnCo record paper-waddell-whole-genomes-pancreatic-nature-2015 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-waddell-whole-genomes-pancreatic-nature-2015/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-waddell-whole-genomes-pancreatic-nature-2015" ;
  schema:name "Whole genomes redefine the mutational landscape of pancreatic cancer"@en ;
  schema:description "The 2015 whole-genome study of 100 pancreatic cancers that sorted them by how broken their chromosomes were and noticed that the most unstable tumours, often with BRCA-type defects, responded to platinum chemotherapy."@en ;
  schema:url <https://onco.cc/key-papers/paper-waddell-whole-genomes-pancreatic-nature-2015/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature14169>, <https://pubmed.ncbi.nlm.nih.gov/25719666/> ;
  onco:tag "pancreatic-evidence" ;
  schema:sameAs <https://doi.org/10.1038/nature14169> ;
  schema:datePublished "2015"^^xsd:gYear ;
  schema:author "Waddell N, Pajic M, Patch AM, et al." ;
  onco:related <https://onco.cc/key-papers/paper-bailey-molecular-subtypes-pancreatic-nature-2016/>, <https://onco.cc/key-papers/paper-polo-olaparib-maintenance-gbrca-pancreatic-nejm-2019/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/brca-palb2-pdac/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/platinum/>, <https://onco.cc/technologies/hrd-testing/> ;
  onco:targets <https://onco.cc/targets/brca/>, <https://onco.cc/targets/palb2/>, <https://onco.cc/targets/kdm6a/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/smad4/>, <https://onco.cc/targets/cdkn2a/>, <https://onco.cc/targets/her2/> ;
  onco:institutions <https://onco.cc/institutions/garvan-institute/> ;
  onco:pathways <https://onco.cc/pathways/ddr/>, <https://onco.cc/pathways/homologous-recombination-repair/>, <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/mutagenesis-signatures/> ;
  onco:terms <https://onco.cc/terms/platinum-sensitivity/>, <https://onco.cc/terms/gbrca-mutation/>, <https://onco.cc/terms/hrd/>, <https://onco.cc/terms/mutational-signature/> ;
  onco:journals <https://onco.cc/journals/nature/> .