# OnCo record paper-wang-notch-pest-mutations-tnbc-ccr-2015 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-wang-notch-pest-mutations-tnbc-ccr-2015/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-wang-notch-pest-mutations-tnbc-ccr-2015" ;
  schema:name "PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a gamma-secretase inhibitor"@en ;
  schema:description "Mutations that destroy the off-switch (PEST domain) of NOTCH1, NOTCH2 and NOTCH3, plus focal amplifications, cluster in triple-negative tumours in TCGA and made patient-derived tumours highly sensitive to a gamma-secretase inhibitor."@en ;
  schema:url <https://onco.cc/key-papers/paper-wang-notch-pest-mutations-tnbc-ccr-2015/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/1078-0432.CCR-14-1348>, <https://pubmed.ncbi.nlm.nih.gov/25564152/> ;
  schema:sameAs <https://doi.org/10.1158/1078-0432.CCR-14-1348> ;
  schema:datePublished "2015"^^xsd:gYear ;
  schema:author "Wang K, Zhang Q, Li D, et al." ;
  onco:cancers <https://onco.cc/cancers/tnbc/> ;
  onco:targets <https://onco.cc/targets/notch1/>, <https://onco.cc/targets/gamma-secretase/> ;
  onco:pathways <https://onco.cc/pathways/notch/> ;
  onco:journals <https://onco.cc/journals/clinical-cancer-research/> .