# OnCo record paper-weisenberger-cimp-braf-mlh1-colorectal-nat-genet-2006 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-weisenberger-cimp-braf-mlh1-colorectal-nat-genet-2006/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-weisenberger-cimp-braf-mlh1-colorectal-nat-genet-2006" ;
  schema:name "CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer"@en ;
  schema:description "Some bowel cancers switch off large numbers of genes by chemical tagging. This study settled a long argument by showing that those tumours are a genuinely distinct group, that they nearly all carry a BRAF mutation, and that they are where sporadic loss of the DNA spell-checker comes from."@en ;
  schema:url <https://onco.cc/key-papers/paper-weisenberger-cimp-braf-mlh1-colorectal-nat-genet-2006/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/ng1834>, <https://pubmed.ncbi.nlm.nih.gov/16804544/> ;
  schema:sameAs <https://doi.org/10.1038/ng1834> ;
  schema:datePublished "2006"^^xsd:gYear ;
  schema:author "Weisenberger DJ, Siegmund KD, Campan M, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/methylation-profiling/> ;
  onco:targets <https://onco.cc/targets/braf/>, <https://onco.cc/targets/mlh1/>, <https://onco.cc/targets/mmr/> ;
  onco:pathways <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/mismatch-repair-msi/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/lynch-syndrome/> ;
  onco:journals <https://onco.cc/journals/nature-genetics/> .