# OnCo record paper-witkiewicz-pancreatic-exomes-utsw-nat-commun-2015 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-witkiewicz-pancreatic-exomes-utsw-nat-commun-2015/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-witkiewicz-pancreatic-exomes-utsw-nat-commun-2015" ;
  schema:name "Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets"@en ;
  schema:description "By cutting the cancer cells out from the surrounding scar tissue before sequencing 109 tumours, this study got cleaner mutation calls and found that MYC gain marks the worst outcomes, that codon-61 KRAS and RBM10 changes go with longer survival, and that BRAF-mutant tumours lack KRAS and respond to BRAF drugs in models."@en ;
  schema:url <https://onco.cc/key-papers/paper-witkiewicz-pancreatic-exomes-utsw-nat-commun-2015/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/ncomms7744>, <https://pubmed.ncbi.nlm.nih.gov/25855536/>, <https://www.cbioportal.org/study/summary?id=paad_utsw_2015> ;
  schema:sameAs <https://doi.org/10.1038/ncomms7744> ;
  schema:datePublished "2015"^^xsd:gYear ;
  schema:author "Witkiewicz AK, McMillan EA, Balaji U, et al." ;
  onco:cancers <https://onco.cc/cancers/pancreatic/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/myc-gene/>, <https://onco.cc/targets/braf/>, <https://onco.cc/targets/rnf43/> ;
  onco:institutions <https://onco.cc/institutions/utsw-simmons/> ;
  onco:pathways <https://onco.cc/pathways/myc/>, <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/wnt/> ;
  onco:terms <https://onco.cc/terms/kras-mutation-subtypes/> ;
  onco:journals <https://onco.cc/journals/nature-communications/> .