# OnCo record paper-yachida-metastasis-late-genetic-evolution-pancreatic-nature-2010 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-yachida-metastasis-late-genetic-evolution-pancreatic-nature-2010/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-yachida-metastasis-late-genetic-evolution-pancreatic-nature-2010" ;
  schema:name "Distant metastasis occurs late during the genetic evolution of pancreatic cancer"@en ;
  schema:description "Comparing the genomes of primary tumours and their metastases put numbers on the timeline: about ten years from the first mutation to a fully formed tumour, five more before it can spread, and two years of life after that, so there is a long window in which the cancer could be caught."@en ;
  schema:url <https://onco.cc/key-papers/paper-yachida-metastasis-late-genetic-evolution-pancreatic-nature-2010/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature09515>, <https://pubmed.ncbi.nlm.nih.gov/20981102/> ;
  schema:sameAs <https://doi.org/10.1038/nature09515> ;
  schema:datePublished "2010"^^xsd:gYear ;
  schema:author "Yachida S, Jones S, Bozic I, et al." ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/metastatic-pdac/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/pancreatic-surveillance/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:pathways <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/metastatic-cascade/> ;
  onco:people <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/kenneth-kinzler/> ;
  onco:journals <https://onco.cc/journals/nature/> .