# OnCo record parg (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/parg/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "parg" ;
  schema:name "PARG"@en ;
  schema:alternateName "poly(ADP-ribose) glycohydrolase"@en, "PARG" ;
  schema:description "PARG clears away the poly(ADP-ribose) chains that PARP enzymes lay down at damaged DNA. Blocking it is meant to deepen the replication stress some cancers already live with, as a partner or alternative to PARP inhibitors; two PARG inhibitors are in trials."@en ;
  schema:url <https://onco.cc/targets/parg/> ;
  schema:dateModified "2026-11-03"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8605>, <https://www.uniprot.org/uniprotkb/Q86W56/entry>, <https://www.ncbi.nlm.nih.gov/gene/8505>, <https://doi.org/10.1101/gad.334516.119> ;
  onco:tag "pipeline-gap-target" ;
  onco:targetClass "enzyme" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8605>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000227345>, <https://www.uniprot.org/uniprotkb/Q86W56/entry>, <https://www.ncbi.nlm.nih.gov/gene/8505> ;
  onco:related <https://onco.cc/targets/parp/> ;
  onco:cancers <https://onco.cc/cancers/metastatic-cancer/> ;
  onco:drugs <https://onco.cc/drugs/dat-2645/>, <https://onco.cc/drugs/etx-19477/> .