# OnCo record parp-plus-arpi (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/parp-plus-arpi/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "parp-plus-arpi" ;
  schema:name "PARP inhibitor + AR pathway inhibitor (prostate)"@en ;
  schema:description "In prostate cancer, blocking androgen signalling makes cells more dependent on PARP, and PARP inhibition weakens AR signalling in turn."@en ;
  schema:url <https://onco.cc/pairings/parp-plus-arpi/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/EVIDoa2200043>, <https://doi.org/10.1016/S0140-6736(23)01055-3> ;
  onco:cancers <https://onco.cc/cancers/prostate/> ;
  onco:drugs <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/talazoparib/>, <https://onco.cc/drugs/niraparib/> ;
  onco:pathways <https://onco.cc/pathways/ddr/>, <https://onco.cc/pathways/ar-signaling/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-clarke-nejm-evid/> ;
  onco:pairs <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/androgen-deprivation/> .