# OnCo record pbd-sg3199 (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/pbd-sg3199/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "pbd-sg3199" ;
  schema:name "PBD dimer (SG3199 / tesirine)"@en ;
  schema:alternateName "pyrrolobenzodiazepine dimer"@en, "tesirine payload"@en, "SG3199"@en ;
  schema:description "The PBD dimer SG3199 crosslinks DNA in the minor groove without distorting it, so cells fail to detect the damage; it kills at picomolar concentrations, so ADCs need only a low drug-to-antibody ratio. Fluid retention, skin reactions and light sensitivity stopped several programmes; loncastuximab tesirine in large B-cell lymphoma is the approved example."@en ;
  schema:url <https://onco.cc/terms/pbd-sg3199/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Pyrrolobenzodiazepine> ;
  owl:sameAs <http://www.wikidata.org/entity/Q25098872> ;
  schema:citation <https://en.wikipedia.org/wiki/Pyrrolobenzodiazepine> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/zynlonta/> ;
  onco:terms <https://onco.cc/terms/payload/>, <https://onco.cc/terms/pbd-dimer-payloads/> .