# OnCo record pd-ligand-9p24-alteration (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/pd-ligand-9p24-alteration/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "pd-ligand-9p24-alteration" ;
  schema:name "9p24.1 alteration of the PD-1 ligand loci"@en ;
  schema:alternateName "9p24.1 amplification"@en, "CD274 amplification"@en, "PDCD1LG2 amplification"@en, "PD-1 ligand copy gain"@en, "9p24.1 copy gain"@en ;
  schema:description "An extra stretch of chromosome 9 that carries both of the molecules a tumour uses to switch off T cells, plus the enzyme that turns them up further. Nearly every classical Hodgkin lymphoma has it, which is why checkpoint drugs work so well there and so poorly in most other lymphomas."@en ;
  schema:url <https://onco.cc/biomarkers/pd-ligand-9p24-alteration/> ;
  schema:dateModified "2026-09-30"^^xsd:date ;
  schema:citation <https://doi.org/10.1182/blood-2010-05-282780>, <https://doi.org/10.1200/JCO.2016.66.4482>, <https://doi.org/10.1200/JCO.2017.77.3994>, <https://doi.org/10.1056/NEJMoa1411087> ;
  onco:tag "biomarker", "lymphoma" ;
  onco:cancers <https://onco.cc/cancers/hodgkin-lymphoma/>, <https://onco.cc/cancers/primary-mediastinal-b-cell-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/cytogenetics-fish/>, <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/jak2/>, <https://onco.cc/targets/ciita/> ;
  onco:drugs <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/pembrolizumab/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/jak-stat/>, <https://onco.cc/pathways/antigen-presentation-immunoediting/> ;
  onco:terms <https://onco.cc/terms/lymphoma-bio-hodgkin-microenvironment/>, <https://onco.cc/terms/gene-amplification/>, <https://onco.cc/terms/fish/> .