# OnCo record pdgfra-exon-18-d842v (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/pdgfra-exon-18-d842v/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "pdgfra-exon-18-d842v" ;
  schema:name "PDGFRA exon 18 mutation (D842V)"@en ;
  schema:alternateName "PDGFRA D842V"@en, "D842V"@en, "PDGFRA exon 18"@en, "PDGFRA exon 18 mutation"@en, "PDGFRA-mutant GIST"@en ;
  schema:description "PDGFRA D842V drives about 5 percent of gastrointestinal stromal tumours and is resistant to imatinib. Avapritinib is the approved drug for GISTs with PDGFRA exon 18 mutations including D842V."@en ;
  schema:url <https://onco.cc/biomarkers/pdgfra-exon-18-d842v/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=645c887c-8cd4-4623-8da9-ac223d71a8b9> ;
  onco:tag "biomarker", "gist" ;
  onco:related <https://onco.cc/biomarkers/kit-d816v/> ;
  onco:cancers <https://onco.cc/cancers/gist/>, <https://onco.cc/cancers/gist-pdgfra-d842v/> ;
  onco:drugs <https://onco.cc/drugs/avapritinib/>, <https://onco.cc/drugs/imatinib/>, <https://onco.cc/drugs/therascreen-cdx/> ;
  onco:terms <https://onco.cc/terms/gist-risk-stratification/> .