# OnCo record pevonedistat (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/pevonedistat/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "pevonedistat" ;
  schema:name "Pevonedistat"@en ;
  schema:alternateName "TAK-924"@en, "MLN4924"@en ;
  schema:description "Pevonedistat was a first-in-class drug that jammed part of the cell's protein-disposal system. Promising with azacitidine in a mid-stage trial for higher-risk myelodysplastic syndromes, it failed to beat azacitidine alone in the phase 3 PANTHER trial in 2021."@en ;
  schema:url <https://onco.cc/drugs/pevonedistat/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Pevonedistat> ;
  schema:citation <https://en.wikipedia.org/wiki/Pevonedistat> ;
  onco:status "negative" ;
  onco:tag "subtype-drugs-wave" ;
  onco:modality "Intravenous NEDD8-activating enzyme (NAE) inhibitor" ;
  onco:related <https://onco.cc/drugs/azacitidine/> ;
  onco:cancers <https://onco.cc/cancers/mds-higher-risk/> ;
  onco:companies <https://onco.cc/companies/takeda/> .