# OnCo record philadelphia-chromosome (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/philadelphia-chromosome/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "philadelphia-chromosome" ;
  schema:name "Philadelphia chromosome (Ph+, BCR::ABL1)"@en ;
  schema:alternateName "Philadelphia"@en, "Ph+"@en, "Ph-positive"@en, "Ph-negative"@en, "BCR-ABL"@en, "BCR-ABL1"@en, "BCR::ABL1"@en, "t(9;22)"@en, "Philadelphia-positive"@en, "Ph+ ALL"@en, "p190 transcript"@en, "p210 transcript"@en, "BCR::ABL1 transcript type"@en ;
  schema:description "A swapped piece between chromosomes 9 and 22 that fuses two genes into BCR::ABL1, a runaway kinase. It causes chronic myeloid leukaemia and a hard-to-treat quarter of adult acute lymphoblastic leukaemia, and was the target of imatinib, the first modern targeted cancer drug."@en ;
  schema:url <https://onco.cc/terms/philadelphia-chromosome/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Philadelphia_chromosome> ;
  schema:citation <https://en.wikipedia.org/wiki/Philadelphia_chromosome> ;
  onco:related <https://onco.cc/terms/molecular-response/>, <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/cytogenetics/>, <https://onco.cc/terms/tki-term/> ;
  onco:cancers <https://onco.cc/cancers/all-leukemia/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/> ;
  onco:drugs <https://onco.cc/drugs/imatinib/>, <https://onco.cc/drugs/dasatinib/>, <https://onco.cc/drugs/ponatinib/>, <https://onco.cc/drugs/asciminib/>, <https://onco.cc/drugs/blinatumomab/> .