# OnCo record pi3k-pathway-plus-endocrine (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/pi3k-pathway-plus-endocrine/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "pi3k-pathway-plus-endocrine" ;
  schema:name "PI3K/AKT-pathway inhibitor + endocrine therapy (± CDK4/6)"@en ;
  schema:description "Blocking the PI3K growth pathway alongside hormone therapy works only when the tumour carries a mutation in that pathway, and works best early."@en ;
  schema:url <https://onco.cc/pairings/pi3k-pathway-plus-endocrine/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2404625>, <https://doi.org/10.1056/NEJMoa2214131> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:targets <https://onco.cc/targets/pik3ca/>, <https://onco.cc/targets/akt/> ;
  onco:drugs <https://onco.cc/drugs/inavolisib/>, <https://onco.cc/drugs/capivasertib/>, <https://onco.cc/drugs/alpelisib/>, <https://onco.cc/drugs/fulvestrant/> ;
  onco:pathways <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/er-signaling/> ;
  onco:pairs <https://onco.cc/drugs/inavolisib/>, <https://onco.cc/technologies/endocrine-therapy/> .