# OnCo record pkpd-modelling (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/pkpd-modelling/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "pkpd-modelling" ;
  schema:name "Pharmacokinetic and pharmacodynamic modelling"@en ;
  schema:description "Equations that describe how a drug's concentration rises and falls in the body and how that concentration translates into effect and toxicity; the reason doses are given per square metre, why some drugs are infused over days, and how children's doses are set."@en ;
  schema:url <https://onco.cc/technologies/pkpd-modelling/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://en.wikipedia.org/wiki/Pharmacokinetics>, <https://doi.org/10.1200/JCO.1989.7.11.1748> ;
  onco:status "established" ;
  onco:tag "mathematical-model" ;
  onco:sections <https://onco.cc/fronts/ai-computation/>, <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/technologies/oncology-pharmacogenomics/>, <https://onco.cc/technologies/quantitative-systems-pharmacology/> ;
  onco:drugs <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/methotrexate/>, <https://onco.cc/drugs/busulfan/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-calvert-j-clin-oncol/> .