# OnCo record plk4 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/plk4/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "plk4" ;
  schema:name "PLK4"@en ;
  schema:alternateName "polo like kinase 4"@en, "polo-like kinase 4"@en, "STK18"@en, "PLK4" ;
  schema:description "PLK4 is the enzyme that starts the copying of the centrosome, the structure that organises a dividing cell's spindle. Cancers with extra copies of the TRIM37 gene cannot divide properly once PLK4 is blocked, and two PLK4 inhibitors are in early trials."@en ;
  schema:url <https://onco.cc/targets/plk4/> ;
  schema:dateModified "2026-11-03"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11397>, <https://www.uniprot.org/uniprotkb/O00444/entry>, <https://www.ncbi.nlm.nih.gov/gene/10733>, <https://doi.org/10.1038/s41586-020-2710-1> ;
  onco:tag "pipeline-gap-target" ;
  onco:targetClass "kinase" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11397>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000142731>, <https://www.uniprot.org/uniprotkb/O00444/entry>, <https://www.ncbi.nlm.nih.gov/gene/10733> ;
  onco:cancers <https://onco.cc/cancers/neuroblastoma/>, <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/mds/> ;
  onco:drugs <https://onco.cc/drugs/cfi-400945/>, <https://onco.cc/drugs/rp-1664/> .