# OnCo record pole-ultramutation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/pole-ultramutation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "pole-ultramutation" ;
  schema:name "POLE ultramutation (POLEmut)"@en ;
  schema:alternateName "POLE"@en, "POLE mutation"@en, "POLE-mutated"@en, "POLEmut"@en, "POLE exonuclease domain mutation"@en, "POLE EDM"@en, "ultramutated"@en, "ultramutation"@en, "POLE ultramutated"@en, "POLE hotspot mutation"@en ;
  schema:description "A pathogenic mutation in the proofreading part of the POLE gene gives an endometrial tumour hundreds of mutations per megabase and, paradoxically, one of the best outlooks of any womb cancer, so finding it can spare a woman chemotherapy or radiotherapy."@en ;
  schema:url <https://onco.cc/terms/pole-ultramutation/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/POLE_(gene)> ;
  schema:citation <https://en.wikipedia.org/wiki/POLE_(gene)> ;
  onco:related <https://onco.cc/terms/endometrial-molecular-classes/>, <https://onco.cc/terms/nsmp/>, <https://onco.cc/terms/tmb/>, <https://onco.cc/terms/ngs/>, <https://onco.cc/terms/tp53-mutated/>, <https://onco.cc/terms/msi/>, <https://onco.cc/drugs/pembrolizumab/> ;
  onco:cancers <https://onco.cc/cancers/endometrial-pole-ultramutated/>, <https://onco.cc/cancers/advanced-recurrent-endometrial-cancer/>, <https://onco.cc/cancers/uterine-carcinosarcoma/> .