# OnCo record pole (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/pole/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "pole" ;
  schema:name "POLE"@en ;
  schema:alternateName "DNA polymerase epsilon, catalytic subunit"@en, "DNA polymerase epsilon catalytic subunit A"@en, "POLE1"@en, "POLE" ;
  schema:description "POLE (DNA polymerase epsilon catalytic subunit A) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a biomarker and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Colorectal cancer, Ovarian cancer, Lung cancer and 5 more."@en ;
  schema:url <https://onco.cc/targets/pole/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9177>, <https://www.uniprot.org/uniprotkb/Q07864/entry>, <https://www.ncbi.nlm.nih.gov/gene/5426>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177084> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "oncogene" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9177>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177084>, <https://www.uniprot.org/uniprotkb/Q07864/entry>, <https://www.ncbi.nlm.nih.gov/gene/5426> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/leukaemia/>, <https://onco.cc/cancers/myeloproliferative-neoplasms/>, <https://onco.cc/cancers/endometrial/> ;
  onco:trials <https://onco.cc/trials/rainbo/> .