# OnCo record polygenic-risk-score (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/polygenic-risk-score/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "polygenic-risk-score" ;
  schema:name "Polygenic risk score (PRS)"@en ;
  schema:alternateName "PRS"@en, "polygenic score"@en, "genetic risk score"@en, "GRS"@en, "SNP risk score"@en, "polygenic risk score prostate"@en ;
  schema:description "A single number adding up hundreds of common, individually tiny genetic differences to say whether a man's inherited risk of prostate cancer is above or below average. It is not a test for a faulty gene like BRCA2, and it says nothing about how aggressive a cancer would be."@en ;
  schema:url <https://onco.cc/terms/polygenic-risk-score/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Polygenic_score> ;
  schema:citation <https://doi.org/10.1038/s41588-020-00748-0>, <https://doi.org/10.1056/nejmoa2407934>, <https://doi.org/10.1111/bju.15535>, <https://doi.org/10.1016/j.euo.2025.12.013>, <https://doi.org/10.1001/jama.2024.3841> ;
  onco:tag "gu", "prostate-glossary" ;
  onco:related <https://onco.cc/technologies/polygenic-risk-scores/>, <https://onco.cc/key-papers/paper-conti-trans-ancestry-gwas-prostate-nat-genet-2021/>, <https://onco.cc/ideas/idea-prev-prs-screening-start-age/>, <https://onco.cc/ideas/idea-prev-mri-first-prostate-screening-prs/>, <https://onco.cc/technologies/germline-testing/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-low-risk/>, <https://onco.cc/cancers/prostate-intermediate-risk/>, <https://onco.cc/cancers/prostate-high-risk/> ;
  onco:sections <https://onco.cc/fronts/prevention/>, <https://onco.cc/fronts/early-detection/>, <https://onco.cc/fronts/diagnostics/> ;
  onco:technologies <https://onco.cc/technologies/polygenic-risk-scores/>, <https://onco.cc/technologies/germline-testing/>, <https://onco.cc/technologies/prostate-screening-psa-mri/>, <https://onco.cc/technologies/mri/> ;
  onco:terms <https://onco.cc/terms/screening/>, <https://onco.cc/terms/overdiagnosis/>, <https://onco.cc/terms/number-needed-to-screen/>, <https://onco.cc/terms/psa/>, <https://onco.cc/terms/lead-time-bias/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-hereditary-risk/>, <https://onco.cc/bottlenecks/b-early-detection/>, <https://onco.cc/bottlenecks/b-trial-diversity/>, <https://onco.cc/bottlenecks/b-overdiagnosis/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-conti-trans-ancestry-gwas-prostate-nat-genet-2021/>, <https://onco.cc/key-papers/paper-goteborg-2-n-engl-j-med-2022/> .