# OnCo record ponsegromab-phase-2 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/ponsegromab-phase-2/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "ponsegromab-phase-2", "NCT05546476" ;
  schema:name "Ponsegromab phase 2 in cancer cachexia"@en ;
  schema:description "The first drug to hit the hormone behind cancer wasting: patients on the highest dose gained nearly 3 kg more than placebo in 12 weeks and reported better appetite and more activity."@en ;
  schema:url <https://onco.cc/trials/ponsegromab-phase-2/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05546476>, <https://doi.org/10.1056/NEJMoa2409515> ;
  onco:status "positive" ;
  onco:phase "2" ;
  schema:startDate "2022-11-21" ;
  onco:related <https://onco.cc/ideas/idea-cachexia-gdf15-prevention/>, <https://onco.cc/ideas/idea-bio2-gdf15-plus-exercise/>, <https://onco.cc/ideas/idea-bio2-gdf15-stratified-enrolment/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/colorectal/> ;
  onco:sections <https://onco.cc/fronts/nutrition-lifestyle/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/cachexia-therapy/>, <https://onco.cc/technologies/cachexia-appetite-pharmacotherapy/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:pathways <https://onco.cc/pathways/cachexia-biology/> ;
  onco:terms <https://onco.cc/terms/cachexia/>, <https://onco.cc/terms/body-composition/> ;
  onco:trials <https://onco.cc/trials/nct06989437/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-cachexia-supportive/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-groarke-ponsegromab-cancer-cachexia-nejm-2024/> .