# OnCo record prame (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/prame/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "prame" ;
  schema:name "PRAME"@en ;
  schema:description "PRAME is a cancer-testis antigen: a protein normally confined to the testis that about 90% of cutaneous melanomas and substantial fractions of ovarian, lung, endometrial and uveal cancers switch on. Because it sits inside the cell, drugs reach it only as peptide fragments displayed on HLA, through T-cell receptor bispecifics such as brenetafusp and TCR-T cells such as IMA203."@en ;
  schema:url <https://onco.cc/targets/prame/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/PRAME>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9336>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185686>, <https://www.uniprot.org/uniprotkb/P78395/entry>, <https://www.ncbi.nlm.nih.gov/gene/23532> ;
  owl:sameAs <http://www.wikidata.org/entity/Q21134188> ;
  schema:citation <https://en.wikipedia.org/wiki/PRAME> ;
  onco:tag "tcr-target" ;
  schema:alternateName "PRAME" ;
  onco:targetClass "other" ;
  onco:firstDescribed "1997"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/sarcoma/> ;
  onco:technologies <https://onco.cc/technologies/t-cell-engager/>, <https://onco.cc/technologies/tcr-t/> ;
  onco:drugs <https://onco.cc/drugs/brenetafusp/>, <https://onco.cc/drugs/ima203/> ;
  onco:companies <https://onco.cc/companies/immunocore/>, <https://onco.cc/companies/immatics/> ;
  onco:terms <https://onco.cc/terms/hla-a02-restriction/> ;
  onco:trials <https://onco.cc/trials/nct05958121/> .