# OnCo record pre-metastatic-niche (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/pre-metastatic-niche/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "pre-metastatic-niche" ;
  schema:name "The pre-metastatic niche"@en ;
  schema:description "Before a single cancer cell arrives, the primary tumour sends parcels ahead: tiny vesicles (exosomes) and hormones that recruit bone-marrow cells to a distant organ and remodel it into fertile soil. By the time the seed lands, the bed is already made."@en ;
  schema:url <https://onco.cc/pathways/pre-metastatic-niche/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Metastasis> ;
  schema:citation <https://doi.org/10.1038/nrc.2017.6> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:technologies <https://onco.cc/technologies/exosome-therapeutics/>, <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/single-cell-spatial/> ;
  onco:targets <https://onco.cc/targets/vegf/>, <https://onco.cc/targets/hif2a/>, <https://onco.cc/targets/csf1r/>, <https://onco.cc/targets/cxcr4/> ;
  onco:drugs <https://onco.cc/drugs/bevacizumab/>, <https://onco.cc/drugs/signatera/> ;
  onco:pathways <https://onco.cc/pathways/metastatic-cascade/>, <https://onco.cc/pathways/intravasation-ctc-survival/>, <https://onco.cc/pathways/organ-tropism-seed-soil/>, <https://onco.cc/pathways/tumor-dormancy/>, <https://onco.cc/pathways/hif-vhl/> ;
  onco:terms <https://onco.cc/terms/disseminated-tumor-cells/>, <https://onco.cc/terms/myeloid-derived-suppressor-cells/>, <https://onco.cc/terms/mrd/>, <https://onco.cc/terms/late-recurrence/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-metastasis-biology/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-peinado-nat-rev-cancer/> .