# OnCo record prima-follicular (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/prima-follicular/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "prima-follicular", "NCT00140582" ;
  schema:name "PRIMA"@en ;
  schema:alternateName "Primary Rituximab and Maintenance"@en, "PRIMA trial"@en, "Rituximab maintenance in follicular lymphoma"@en ;
  schema:description "Two years of an antibody given every two months after chemotherapy more than doubled the time before follicular lymphoma came back, but after nine years the two groups were equally likely to be alive."@en ;
  schema:url <https://onco.cc/trials/prima-follicular/> ;
  schema:dateModified "2026-10-01"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT00140582>, <https://doi.org/10.1016/S0140-6736(10)62175-7>, <https://doi.org/10.1200/JCO.19.01073> ;
  onco:status "mixed" ;
  onco:tag "lymphoma-evidence" ;
  onco:phase "3" ;
  schema:startDate "2004-12" ;
  onco:cancers <https://onco.cc/cancers/follicular-lymphoma/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:sections <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:targets <https://onco.cc/targets/cd20/> ;
  onco:drugs <https://onco.cc/drugs/rituximab/>, <https://onco.cc/drugs/cyclophosphamide/>, <https://onco.cc/drugs/doxorubicin/>, <https://onco.cc/drugs/vincristine/>, <https://onco.cc/drugs/prednisone/> ;
  onco:companies <https://onco.cc/companies/lysa/> ;
  onco:terms <https://onco.cc/terms/maintenance-therapy/>, <https://onco.cc/terms/lymphoma-tx-maintenance/>, <https://onco.cc/terms/flipi/>, <https://onco.cc/terms/watchful-waiting/> ;
  onco:people <https://onco.cc/people/gilles-salles/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-patient-voice/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-prima-rituximab-maintenance-follicular-lancet-2011/>, <https://onco.cc/key-papers/paper-prima-final-rituximab-maintenance-follicular-jco-2019/> .