# OnCo record prime (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/prime/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "prime", "NCT00364013" ;
  schema:name "PRIME"@en ;
  schema:alternateName "Panitumumab Randomized Trial In Combination With Chemotherapy for Metastatic Colorectal Cancer to Determine Efficacy"@en ;
  schema:description "The trial that widened the RAS test from two spots in one gene to all of KRAS and NRAS, because patients with any RAS mutation were harmed by the antibody."@en ;
  schema:url <https://onco.cc/trials/prime/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT00364013>, <https://doi.org/10.1056/NEJMoa1305275> ;
  onco:status "positive" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/nras/>, <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/panitumumab/>, <https://onco.cc/drugs/folfox/>, <https://onco.cc/drugs/oxaliplatin/>, <https://onco.cc/drugs/fluorouracil/> ;
  onco:companies <https://onco.cc/companies/amgen/> ;
  onco:terms <https://onco.cc/terms/sidedness/> ;
  onco:trials <https://onco.cc/trials/crystal-fire3/>, <https://onco.cc/trials/paradigm/>, <https://onco.cc/trials/opus/> .