# OnCo record prkdc (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/prkdc/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "prkdc" ;
  schema:name "PRKDC"@en ;
  schema:alternateName "protein kinase, DNA-activated, catalytic subunit"@en, "DNA-dependent protein kinase catalytic subunit"@en, "DNPK1"@en, "p350"@en, "DNAPK"@en, "XRCC7"@en, "DNA-PKcs"@en, "DNAPKc"@en, "DNA-PKC"@en, "p460"@en, "HYRC1"@en, "PRKDC" ;
  schema:description "PRKDC (DNA-dependent protein kinase catalytic subunit) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma, Non-small-cell lung cancer and Diffuse large B-cell lymphoma."@en ;
  schema:url <https://onco.cc/targets/prkdc/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9413>, <https://www.uniprot.org/uniprotkb/P78527/entry>, <https://www.ncbi.nlm.nih.gov/gene/5591>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000253729> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "kinase" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9413>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000253729>, <https://www.uniprot.org/uniprotkb/P78527/entry>, <https://www.ncbi.nlm.nih.gov/gene/5591> ;
  onco:related <https://onco.cc/collections/civic/> ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/dlbcl/> .